A recent study indicates that patients who discontinue new GLP-1 drugs like Mounjaro or Wegovy can put back on shed pounds far faster than those who end traditional diet and exercise programs.
Findings released in a major health publication points out that while obese individuals often shed substantial amounts of their body weight while undergoing treatment, the weight is regained at an average rate of 0.8 kg per month once they quit.
"Individuals using such treatments need to be aware of the potential of fast weight regain when the treatment concludes," stated researcher Dr. Susan Jebb.
This pace of regain suggests a return to original mass in about 18 months.
Comparing Therapies
The study, which reviewed dozens of trials involving over 9,000 of patients, contrasted the outcomes of these new drugs with older methods.
Scientists note that people who shed pounds through lifestyle changes alone generally see a more gradual creep back—around 0.1 kg a month—once they finish.
Explaining the Quick Rebound
Doctors believe the way of the jabs explains the heightened rebound.
The injections copy a body's own chemical called glucagon-like peptide-1, which moderates feelings of fullness.
"Artificially providing the hormone levels far above than the body's typical production could lead to the body to produce less of its endogenous GLP-1, and may also reduce responsiveness to its actions," explained Dr. Adam Collins, a dietetics expert.
"Discontinuation of this hormone supplement leads to appetite is unsuppressed, making excessive eating a significant risk."
A Chronic Disease?
Medical guidelines suggest the jabs for people with obesity-related health risks, alongside prescribed diet and exercise modifications.
Many experts argue that, due to the significant potential of weight regain, the therapy might need to be ongoing.
This opinion is reinforced by drug manufacturers, who state that the findings "emphasize the persistent character of obesity," akin to managing conditions like diabetes.
User Experiences
Individuals who have come off the jabs report a intense return of hunger.
"It was like a trigger activating and you become ravenous," said an individual.
The struggle is worsened if individuals have not developed lasting dietary or behavioural changes during therapy.
Widespread Adoption
Recent estimates suggest that a significant number of people in the UK have tried these injections in the past year, with interest remaining high.
- Use is greater among females than men.
- The middle-aged demographic shows the greatest level of interest.
- Many obtain the drugs through private healthcare rather than the NHS.
In conclusion, researchers emphasize that while these medications are effective agents for weight loss, they are not a magic solution and maintained weight loss hinges on integrated behavioural support.
